In order to study the fatigue life of multi-component transmission line tension strings under external loads, a method for calculating the fatigue life under multiple combined static loads is proposed. Firstly, a finite element model of transmission line tension strings is established in Abaqus to solve the dynamic stress response under random wind load and the multi-condition static stress response under different combined loads. Through introducing the model into Fe-Safe, the fatigue life under dynamic and different static conditions is calculated. Taking FOS (Factor of Strength) intensity factor as the evaluation index, the differences of fatigue life results between the dynamic and static conditions are examined to explore the influence of stress solutions under different static conditions on the fatigue life results. The results show that the proposed method can effectively improve the calculation efficiency of such structures. The U-shaped and ball-head rings with strong non-linearity are greatly affected by the initial stress and will result in relatively large errors. Nevertheless, within the changing range of the actual load components, the fatigue life prediction results of components under the static and the dynamic conditions do not differ much from each other.